Scientific program

EP05  E-Poster Discussion
E-Poster Discussion 5 at Poster Station 2

07-Feb-2014 10:05 10:25
 
 
Abstract:
CLINICAL UTILITY OF CGM IN PRE-DIABETES AND ITS IMPACT ON MODIFYING LIFESTYLES

Glycemic excursions in pre-diabetes are seldom evaluated in clinical practice.
We assessed clinical utility of CGM in pre-diabetes and its impact on modifying lifestyles to prevent diabetes.
6 patients were enrolled in 3 month study via convenience sampling based on ability and willingness to follow instructions. Mean age 48.5 yrs, mean BMI 26.73 kg/m2. Measured blood glucose were <126 mg/dl during fasting and <150 mg/dl post breakfast. CGM was performed using iPro2 recorder at 0 and 3 months(5-7 days).Advice on lifestyle modifications were repeated once in 2 weeks by a multi-disciplinary team of doctors, dietitians, pharmacist, nurse educators, device technician, psychologist etc. who made detailed analyses of CGM recordings.
Trends observed in CGM at month 0 included hyperglycemic spikes 30- 90 mins after breakfast and dinner and glycemic variability missed in usual SMBG. At 3 months, CGM revealed smooth curves with average weight reduction of 2.35 kgs.(Table)
CGM may prove an excellent tool to unravel glycemic excursions most often missed in SMBG in pre-diabetes patients. CGM could evolve as motivational tool in pre-diabetes patients to prevent progression to overt diabetes.

CGM Parameters
(n =6)
Mean
(mg/dl)
(0 month)
Standard
deviation
(0 month)
Mean
(mg/dl)
(3 months)
Standard
deviation
(3 months)

FBS 110.8 20.77 91 6.42
HbA1c 5.9% 0.38 5.4% 0.28
No: of High Excursion
7.2 5.23 2.2 2.14
No: of Low Excursion
2.8 3.82 1.5 1.52
Highest Sensor Value
178.2 28.99 151.5 6.44
Lowest Sensor Value
66 12.33 73.8 3.06
Duration within 70-40 mg/dl
89.7 9.27 96.3 2.73
 
Co-authors
J. Kesavadev1, A. Shankar1, G. Sanal1, J. Lally1, G. Krishnan1, S. Jothydev1.
1Diabetes, Jothydev's Diabetes Research Centre, Thiruvanathapuram, India.